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The FASTA programs find regions of local or global similarity between Protein or DNA sequences, either by searching Protein or DNA databases, or by identifying local duplications within a sequence. Other programs provide information on the statistical significance of an alignment. Like BLAST, FASTA can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families.
 
Description
Der heuristische FASTA-Algorithmus wurde 1985 von David J. Lipman und William R. Pearson als FASTP für Proteine entwickelt.[1] Das Programm wurde 1988 auf Nukleotide erweitert.[2]

FASTA sucht nach Ähnlichkeiten zwischen Sequenzen oder vergleicht eine gegebene Sequenz mit einer Sequenz-Datenbank. Die Speicherung der Sequenzdaten erfolgt im FASTA-Format.

Eine Anwendung findet der Algorithmus beispielsweise beim SIMAP-Projekt.

[1] Lipman, D.J. & Pearson, W.R. (1985): Rapid and sensitive protein similarity searches. In: Science. Bd. 227, S. 1435–1441. PMID 2983426
[2] Pearson, W.R. & Lipman, D.J. (1988): Improved tools for biological sequence comparison. In: Proc. Natl. Acad. Sci. U.S.A. Bd. 85, S. 2444–2448. PMID 3162770 PDF

Quelle Wikipedia: https://de.wikipedia.org/wiki/FASTA-Algorithmus
Translated by Thomas Kranz
Reviewed by Christoph Gerlach
Located in Package: fasta3-doc Package: fasta3
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